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Vitiligo is an acquired skin disorder caused by the disappearance of pigment cells from the epidermis, and results in well defined white patches that are often symmetrically distributed. It is a cosmetically disfiguring and stigmatizing condition that may lead to psychological problems in daily life. It occurs worldwide in about 1% of the population and in more than 50% of patients, it occurs between the ages of 10-30 years. It affects both sexes equally, though women more often seek remedy. The exact cause is unknown. Various hypothesis have been put forth:
Genetic Factors: Between 30-40% of patients with vitiligo have a positive family history suggesting genetic causation. The exact mode of inheritance is not known; it may be autosomal dominant or polygenic. The risk of vitiligo for children of affected individuals is unknown, but may be less than 10%. Individuals from families with increased prevalence of thyroid disease, diabetes mellitus and vitiligo appear to be at increased risk. Autoimmune Hypothesis: The autoimmune hypothesis is based on the clinical association of vitiligo with a number of disorders that have an autoimmune mechanism like thyroid disease, diabetes mellitus, Addison's disease, pernicious anemia, hypoparathyroidism, alopecia areata, systemic lupus etc. Vitiligo may be associated with endocrinal disorders Neurogenic Hypothesis: This hypothesis holds good only for vitiligo occurring in a segmental or dermatomal distribution. Self-destruction Hypothesis: This suggests that melanocytes destroy themselves due to a defect of natural protective mechanisms that remove the toxic intermediates (indoles) released in the process of melanin synthesis. Precipitating causes for vitiligo in a patient with susceptibility include physical trauma or illness, emotional stress and sunburn. Clinical Features: Clinically, patients present with white patches that could be focal, segmental, generalised (wherein the lesions are symmetrically distributed), lip and tip or acrofacial pattern (where the lesions are seen around the mouth, fingers, toes and lips, nipples and genitalia). Areas subjected to repeated friction and trauma are also likely to be affected. In long standing cases, the hairs within the patches also appear white. Differential Diagnosis: Vitiligo should be differentiated from many conditions that present with pigment dilution like pityriasis alba (dry, scaly patches commonly seen on the face), post-inflammatory hypopigmentation, leprosy, lupus erythematosus, chemical leukoderma and certain nevi (present since birth and non-progressive). Confirmation is by histopathological examination of skin biopsy that shows absence of melanocytes with mild lymphocytic infiltrates. Associated Disorders: Vitiligo can be associated with certain cutaneous diseases like alopecia areata (presenting with smooth, bald patches) and premature greying of the hair. Less than 10% of patients may have uveitis in the eye. Vitiligo can also be associated with systemic diseases like thyroid diseases (40% of cases), pernicious anemia (<5%), diabetes mellitus (1-7%, particularly late onset vitiligo) and can be a part of multiple endocrinopathy syndrome. Course and Prognosis: Spontaneous repigmentation is noted in 10-20% of patients, most frequently in sun-exposed areas in younger patients. This pigmentation is trivial and mainly starts around the hairs. Course is unpredictable; sudden onset followed by a period of stability or slow progression is characteristic. Management: Certain investigations need to be done based on the complete medical examination to rule out/confirm associated disorders. These include thyroid profile, fasting blood glucose, blood profile for pernicious anemia, early morning cortisol estimation, anti nuclear antibody etc. Treatment: Vitiligo is not contagious General measures: Reassurance forms the mainstay of the treatment. Vitiligo is usually mistaken for leprosy and the patients fear of deformities resulting form leprosy. Vitiligo is not contagious. Emotional upsets can worsen the disease. Sunscreens should be used to avoid sunburns of the depigmented patches and also to avoid new lesions when the disease is active. Camouflage using coloured cosmetics is an immediate remedy that the patient can try. Specific treatment should be done in consultation with a dermatologist. This includes
Vitiligo is a treatable disease with any of these methods, provided the right method is started at the right time and continued till the cosmetic improvement is acceptable. Patches that have totally repigmented usually remain so in the absence of injury or sunburn in 85% cases up to 10 years. Those partially repigmented will reverse back when the treatment is discontinued.
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Last Updated: Sep 12, 2010